Join Over 1,900,000 Fans On Facebook!


Our Most Popular Posts:

How To Heal Cavities - The Astonishing Claims Of The Oil Pullers
Scientists Find Sniffing Rosemary Can Increase Memory By 75%
Giant List of 180+ Herbs With Uses And Benefits
600 Reasons Turmeric May Be The World's Most Important Herb
32 Detox Drinks For Cleansing And Weight Loss
10 Strange Home Remedies That Really Work
10 Simple Home Remedies For Cracked Heels
4 Herbs That Relieve Joint Pain
13 Homemade Bread Recipes - Never Buy Bread Again
Essential Oil Treatments For Swollen Ankles, Legs and Feet
How To Get Rid Of Moles With Apple Cider Vinegar
7 All-Natural Ways To Make Your Home Smell Like Paradise
Top 6 Natural Alternatives To Ibuprofen


Bupleurum

Please Share This Page:

Background & General Info

Bupleurum is a genus belong to the Apiaceae or parsley family and comprises a number of annual and perennial shrubs and herbs. Bupleurum chinense and Bupleurum scorzonerifolium are extensively distributed in the grasslands, stream banks, forest margins, sunny slopes, and roadsides of China, Japan, and Korea. [1] Bupleurum falcatum is endemic to Europe and Western Asia.



Botany

Bupleurum chinense is an herbaceous perennial plant characterized by erect, tufted stems and alternately arranged leaves with broadly linear-lanceolate leaf blades and acuminate apex. Its roots are conical and taupe. The five-petal, bright yellow flowers are borne from axillary and terminal compound umbels, with the plant blossoming from July to September. During the months of August to October, the plant bears oblong, brown fruits that are approximately 3 mm in length. [1] Bupleurum falcatum is a perennial that can grow up to a meter tall. Its lanceolate basal leaves have broad upper lamina, whereas its linear to lanceolate middle and upper leaves are gradually shorter and falcate. [2]

Bupleurum scorzonerifolium is another herbaceous perennial plant. Its primary features consist of usually glabrous stems; reddish brown roots; and linear or linear-lanceolate leaves with acuminate apex. Its yellow flowers comprise five petals as well and its fruits are ellipsoid and dark brown. [1]

History & Traditional Use

The dried roots of Bupleurum falcatum are traditionally used in folk medicine as an anti-inflammatory and antioxidative remedy. [3] In traditional oriental medicine, they are also broadly used as remedy to psychosomatic disorders. [4]

In Asian countries such as China, Japan, and Korea, Radix Bupleuri, which refers to the dried roots of Bupleurum chinense and Bupleurum scorzonerifolium, has been traditionally used as medicine for more than 2000 years for influenza, fever, inflammation, malaria, menstrual disorders, and hepatitis. [5] Ancient Chinese medical literatures mentioned its ability to normalize the exterior and interior metabolisms, diffuse “evil heat” from the surface, soothe the liver, and promote yang and qi (“life force”). [6]

General Herbal Uses

A number of scientific studies have been conducted on many species of genus Bupleurum, which generated massive data about their extracts’ biological activities. [5] Triterpene saponins isolated from Bupleurum species have been shown to exhibit immunomodulatory, anti-inflammatory, and antiviral activities, and several saikosaponins from Bupleurum display very potent anti-inflammatory, hepatoprotective, and immunomodulatory actions both in vivo and in vitro. [5]



Constituents/Active Components

Chemical profiling of genus Bupleurum characterized numerous groups of secondary metabolites with important biological activities, including triterpene saponins (especially saikosaponins), lignans, essential oils, and polysaccharides. [5] Gas chromatography–mass spectrometry (GC–MS) analysis by Shi et al. (2010) on the essential oil from Bupleurum longiradiatum roots identified 51 compounds, including thymol (7.0%), butylidene phthalide (6.8%), 5-indolol (5.6%), heptanal (5.3%), 4-hydroxy-2-methylacetophenone (5.3%), 4,5-diethyl-octane (5.3%), bormeol (5.1%), and hexanoic acid (5.1%). [7] A 2013 Iranian study also screened the chemical composition of water-distilled essential oils from the aerial parts of Bupleurum falcatum and Bupleurum gerardi. α-Pinene (29.4%) and spathulenol (27.7%) were identified as the major compounds of Bupleurum falcatum essential oil, whereas higher amounts of undecane (62.9%) and germacrene D (11.1%) were isolated from Bupleurum gerardi essential oil. [8]

Medicinal/Scientific Research

Anticancer

A 2015 Chinese study confirmed the anticancer, apoptotic, and antioxidant properties of extract from Bupleurum chinense roots against human epithelial ovarian cancer cells (HO-8910) in vitro and further explained that such anticancer property was mediated by induction of apoptosis, DNA fragmentation, and disruption of mitochondrial membrane potential. In the MTT assay, Bupleurum chinense root extract exerted potent and dose-dependent cytotoxic effects against the cancer cells and stimulated apoptosis, as evidenced by cell shrinkage, chromatin condensation, and membrane blebbing. In the Annexin V/PI double staining assay, which was used to quantify percentage of apoptotic cells, there was a marked rise in the average proportion of total apoptotic cells, from 9.4% in control cells to 18.5, 28.2, and 50.5% in cells treated with the extract at doses of 20, 80, and 120 μg/mL, respectively. [9]

Antitumor components of Bupleurum, especially saikosaponins A and D, have been proven to be potent against human hepatoma cells as well as other human cell lines. In the study of Motoo and Sawabu (1994), 20 µg/mL of saikosaponin D and 50 µg/mL of saikosaponin A inhibited the cell growth of human PLC/PRF/5 hepatoma cells by 50%. Saikosaponin A in particular suppressed the growth and DNA synthesis of tested human hepatoma cell lines, human liver cells, and human pancreatic cancer cell line. [10]

Anti-inflammatory

Initial studies on the genus Bupleurum had paid particular attention only on the traditional uses of several Bupleurum species as treatment of inflammatory disorders and infectious diseases. [5] An early study in 1975 confirmed the anti-inflammatory property of saikosaponins A and D isolated from Bupleurum falcatum roots using female albino rats. [11] In the study of Bermejo Benito et al. (1998), saikosaponins isolated from Bupleurum rigidum displayed potent in vivo anti-inflammatory activity on experimental mouse ear edema and showed a substantial effect on cellular systems that generate cyclooxygenase and lipoxygenase metabolites. [12]

Hepatoprotective

In an early animal study, pretreatment of saikosaponin D extracted from Bupleurum falcatum roots had been shown to remarkably protect the liver against carbon tetrachloride-induced injury in rats, preventing acute damage and significantly inhibiting lipid peroxidation. Saikosaponin D also minimized the severity of cirrhosis caused by constant injection of carbon tetrachloride in treated rats. [13]

Depression And Anxiety

Administration of Bupleurum falcatum extract had been shown to significantly alleviate depression and anxiety-like behaviors, perhaps via central adrenergic mechanisms. By employing the forced swimming test and elevated plus maze test in rats that had been exposed to repeated restraint stress, Lee et al. (2012) investigated the effect of Bupleurum falcatum extract on the rodents’ behavioral responses. Intraperitoneal pretreatment of rodents with Bupleurum falcatum extract at daily doses of 20, 50, or 100 mg/kg for 15 days resulted in a significant reduction in immobility in the forced swimming test and augmented open-arm exploration in the elevated plus maze test. Additionally, findings from the immunohistochemical examination revealed that the extract prevented any increase in the expression of tyrosine hydroxylase in the locus coeruleus (a nucleus located in the brain stem) of treated rats that underwent restraint stress. [14]

Memory Impairment

Lee et al.’s (2009) research results revealed the protective property of Bupleurum falcatum against neuronal and cognitive impairments caused by repeated immobilization stress in rats and its potential utility in mitigating stress-induced memory impairment. In this study, 14-day oral treatment of Bupleurum falcatum at a dose of 150, 300, or 600 mg/kg in rats before their exposure to repeated immobilization stress resulted in noteworthy enhancement in escape latency (time required to find the platform) in the Morris water maze test and triggered an anxiolytic-like effect in the elevated plus maze behavioral test. Moreover, Bupleurum falcatum treatment significantly lessened the loss in cholinergic immunoreactivity due to repeated immobilization stress in the hippocampus. [4]

Hyperthyroidism

Being a source of antioxidants, Bupleurum falcatum has been considered as a medicinal plant that can be of value against numerous endocrine diseases. Findings from the study of Kim et al. (2012) indicated the benefits of water extract derived from Bupleurum falcatum in ameliorating hyperthyroidism and its associated organ damage. In a rat model wherein hyperthyroidism was elicited by using L-thyroxine, oral treatment of Bupleurum falcatum water extract at doses of 300, 150, and 75 mg/kg for 15 days led to a dose-dependent reversal of hyperthyroidism and its effects, stabilizing L-thyroxine-induced liver oxidative stresses and decreasing alterations in liver and epididymal fats. [3]

Peptic Ulcers

Oral administration of BR-2, an antiulcer polysaccharide fraction from Bupleurum falcatum, in rats had been demonstrated in a 2002 study to be effective in promoting healing of acetic acid-induced chronic ulcers. [15]

Allergic Asthma

Saikosaponin A, which is isolated from Bupleurum falcatum extract, had been demonstrated by Park et al. (2002) to dose-dependently hamper the passive cutaneous anaphylaxis reaction in rats at an intravenous dose greater than 1 mg/kg and hence to display an inhibitory activity against allergic asthma. Maximum inhibition of nearly 60% was achieved at a dose of 10 mg/kg. At doses of 3 and 10 mg/kg, this active compound prevented the bronchoconstriction associated with asthma in sensitized guinea pigs. However, it only weakly inhibited the histamine-induced tracheal contraction in guinea pigs, as well as the histamine release in mast cells of experimental rats. [16]

Contraindications, Interactions, And Safety

The herbal use of Bupleurum is generally considered safe, with no contraindications having been concretely established. However, long-term use of the herb in clinical applications has been reported to cause liver toxicity, which is manifested by transaminase lifts, hepatitis, and jaundice. [6] A 2016 review of reports on adverse events resulting from the use of complementary and alternative medicine within the period of 2009 to 2014 found 11 hepatotoxicity cases (31.4%) associated with Radix Bupleuri use out of the 57 reports eligible for analysis. [17] Liver functions nonetheless return to normal after some time. [6] Side effects include mild lethargy, sedation, and drowsiness, as well as flatulence and bowel movements in large doses. [18]

References:

[1] Editorial Board of Flora of China. Flora of China, Beijing: Science Publishing House, 1998.

[2] "Bupleurum falcatum: Chinese Thoroughwax," Encyclopedia of Life. http://eol.org/pages/2875997/details

[3] S.-M. Kim, S.-C. Kim, I.-K. Chung, W.-H. Cheon and S.-K. Ku, "Antioxidant and protective effects of Bupleurum falcatum on the L-thyroxine-induced hyperthyroidism in rats," Evidence-Based Complementary and Alternative Medicine, vol. 2012, p. 578497, 2012. https://www.ncbi.nlm.nih.gov/pubmed/21748206

[4] B. Lee, I. Shim, H. Lee and D. Hahm, "Effect of Bupleurum falcatum on the stress-induced impairment of spatial working memory in rats," Biological and Pharmaceutical Bulletin, vol. 32, no. 8, p. 1392–1398, 2009. https://www.ncbi.nlm.nih.gov/pubmed/19652379

[5] M. Ashour and M. Wink, "Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action," Journal of Pharmacy and Pharmacology, vol. 63, no. 3, p. 305–321, 2011. https://www.ncbi.nlm.nih.gov/pubmed/21749378

[6] F. Yang, . X. Dong, X. Yin, W. Wang, L. You and J. Ni, "Radix Bupleuri: a review of traditional uses, botany, phytochemistry, pharmacology, and toxicology," BioMed Research International, vol. 2017, p. 7597596, 2017. https://www.ncbi.nlm.nih.gov/pubmed/28593176

[7] B. Shi, W. Liu, S. Wei and W. Wu, "Chemical composition, antibacterial and antioxidant activity of the essential oil of Bupleurum longiradiatum," Natural Product Communications, vol. 5, no. 7, p. 1139–1142, 2010. https://www.ncbi.nlm.nih.gov/pubmed/20734959

[8] A. Rustaiyan, N. Masnabadi, S. Masoudi, et al., "Composition of the essential oils of Bupleurum falcatum L. and Bupleurum gerardi All. from Iran," Journal of Essential Oil Bearing Plants, vol. 13, no. 6, p. 727–731, 2010. www.tandfonline.com/doi/abs/10.1080/0972060X.2010.10643886

[9] L. Gu, Z. Chen, J. Zhao, et al., "Antioxidant, anticancer and apoptotic effects of the Bupleurum chinense root extract in HO-8910 ovarian cancer cells," Journal of BUON, vol. 20, no. 5, p. 1341–1349, 2015. https://www.ncbi.nlm.nih.gov/pubmed/26537084

[10] Y. Motoo and N. Sawabu, "Antitumor effects of saikosaponins, baicalin and baicalein on human hepatoma cell lines," Cancer Letters, vol. 86, no. 1, p. 91–95, 1994. https://www.ncbi.nlm.nih.gov/pubmed/7954360

[11] M. Yamamoto, A. Kumagai and Y. Yamamura, "Structure and actions of saikosaponins isolated from Bupleurum falcatum L. I. Anti-inflammatory action of saikosaponins," Arzneimittelforschung, vol. 25, no. 7, p. 1021–1023, 1975. https://www.ncbi.nlm.nih.gov/pubmed/1174407

[12] P. Bermejo Benito, M. Abad Martínez, A. Silván Sen, et al., "In vivo and in vitro antiinflammatory activity of saikosaponins," Life Sciences, vol. 63, no. 13, p. 1147–1156, 1998. https://www.ncbi.nlm.nih.gov/pubmed/9763210

[13] H. Abe, M. Sakaguchi, S. Odashima and S. Arichi, "Protective effect of saikosaponin-d isolated from Bupleurum falcatum L. on CCl4-induced liver injury in the rat," Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 320, no. 3, p. 266–271, 1982. https://www.ncbi.nlm.nih.gov/pubmed/7133157

[14] B. Lee, H. Yub, et al., "Bupleurum falcatum prevents depression and anxiety-like behaviors in rats exposed to repeated restraint stress," Journal of Microbiology and Biotechnology, vol. 22, no. 3, p. 422–430, 2012. https://www.ncbi.nlm.nih.gov/pubmed/22450800

[15] T. Matsumoto, X. Sun, et al., "Effect of the antiulcer polysaccharide fraction from Bupleurum falcatum L. on the healing of gastric ulcer induced by acetic acid in rats," Phytotherapy Research, vol. 16, no. 1, p. 91–93, 2002. https://www.ncbi.nlm.nih.gov/pubmed/11807976

[16] K. Park, J. Park, D. Koh and Y. Lim, "Effect of saikosaponin-A, a triterpenoid glycoside, isolated from Bupleurum falcatum on experimental allergic asthma," Phytotherapy Research, vol. 16, no. 4, p. 359–363, 2002. https://www.ncbi.nlm.nih.gov/pubmed/12112293

[17] D. Teo, et al., "Drug-induced liver injury associated with Complementary and Alternative Medicine: a review of adverse event reports in an Asian community from 2009 to 2014," BMC Complementary and Alternative Medicine, vol. 16, p. 192, 2016. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937524/

[18] "Bupleurum," Drugs.com. https://www.drugs.com/npc/bupleurum.html

Article researched and created by Dan Albir for herbs-info.com. © herbs-info.com 2018

Everyone knows green smoothies are healthy, right? However…

Have you heard of a “red” smoothie? If not, check out this story…
The Red Smoothie
Detox Factor
=> “Red” Smoothie Helps Alabama Girl Shed 80lbs!



  1. Famous Chef Sheds 60lbs Researching New Paleo Recipes: Get The Cookbook FREE Here
  2. #1 muscle that eliminates joint and back pain, anxiety and looking fat
  3. Drink THIS first thing in the morning (3 major benefits)
  4. "Red" Smoothie Helps Alabama Girl Shed 80lbs!
  5. [PROOF] Reverse Diabetes with a “Pancreas Jumpstart”
  6. Why Some People LOOK Fat that Aren't
  7. Amazing Secret Techniques To Protect Your Home From Thieves, Looters And Thugs
  8. His wife REFUSED to let them amputate his legs!
  9. Here's What Happens When You "Unlock Your Hip Flexors"
  10. The #1 WORST food that CAUSES Faster Aging  (beware -- Are you eating this?)



If you enjoyed this page:

Privacy Policy | Cookie Policy | GDPR | About This Site